In vitro–in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first-pass elimination of drugs: princip
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Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
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Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect
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Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect
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Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
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Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans | Drug Metabolism & Disposition
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Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
![Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006295219302801-ga1.jpg)
Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect
Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allom
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Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
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PDF) Revisiting the well-stirred model of hepatic clearance: Q H , CL H and F changing in the same direction
![nsatmi on Twitter: "肝代謝のみで消失する薬物の経口投与で、AUCが2倍に上昇する場合。(消化管からの吸収率100%、well- stirred modelに従う) ・肝クリアランスが1/2になる さらに ・非結合形分率が1/2になる ・肝固有クリアランスが1/2になる *肝固有クリアランス ... nsatmi on Twitter: "肝代謝のみで消失する薬物の経口投与で、AUCが2倍に上昇する場合。(消化管からの吸収率100%、well- stirred modelに従う) ・肝クリアランスが1/2になる さらに ・非結合形分率が1/2になる ・肝固有クリアランスが1/2になる *肝固有クリアランス ...](https://pbs.twimg.com/media/EMPmlOTU0AAZ0HD.png:large)